Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics
作者： Alka Bali , Komal Sharma , Abhishek Bhalla , Suman Bala , Dinesh Reddy
DOI: 10.1016/J.EJMECH.2010.02.008
关键词:
摘要: A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing stereotypy assays mice. The 11 12 emerged as important lead showing potential profile. physicochemical similarity new analogs with respect to standard drugs clozapine, ketanserin, ziprasidone risperidone was assessed by calculating from a set 10 properties using software programs. test demonstrated good values drugs. these penetrate blood brain barrier (log BB) computed through an online program obtained suggest permeation.
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