Synthesis and evaluation of meta substituted 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics
作者： Alka Bali , A. C. Dinesh Kumar Reddy
DOI: 10.1007/S00044-012-0038-6
关键词:
摘要: A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized based upon their physicochemical similarity with respect to standard atypical antipsychotic drugs and potential cross the blood–brain barrier (log BB) as calculated by appropriate software programmes. The target compounds were evaluated for activity in apomorphine-induced mesh climbing stereotypy assays mice. 8, 9 10 bearing hydrogen bond acceptor substituents emerged important lead showing higher efficacy along profile.
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