Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect
作者： Alka Bali , Sarika Malhotra , Himjyoti Dhir , Anil Kumar , Ajay Sharma
DOI: 10.1016/J.BMCL.2009.04.019
关键词:
摘要: A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing stereotypic behaviour mice. The 8-hydroxyquinoline ether derivative 14 emerged as an important lead compound showing a potential profile. Employing appropriate physicochemical properties, similarity was assessed with respect to some drugs clozapine, ketanserine, ziprasidone risperidone.
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