Hypoxia-Dependent Retinal Toxicity of NLCQ-1 (NSC 709257) in BALB/c Mice. Comparison with Tirapazamine

摘要: Bioreductive drugs can cause retinal toxicity, mediated by extensive apoptosis in the outer retina of rodents and monkeys. In present study, we have investigated whether or not novel promising hypoxia-selective cytotoxin 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1, NSC 709257) hypoxia-dependent toxicity BALB/c mice alone combination with cyclophosphamide (CPM), one anti-cancer agents that acts synergistically NLCQ-1 against mouse tumours human xenografts. The bioreductive agent tirapazamine (TPZ) was included for comparison purposes. Retinal damage quantified morphometric analysis histological sections following IP treatment female mice. No observed 10 22 mg/kg 23 TPZ alone, whereas statistically significant higher dose 52 (p < 0.001). Thus, a normalized photoreceptor layer thickness (NPT) value 0.50 ± 0.04, 0.48 0.03 0.33 0.06 determined untreated, TPZ-treated at highest dose, respectively. Marginal lower CPM.