Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
作者： S Schreiber , MM Backer , I Herman , D Shamir , T Rigai
DOI:
关键词: Drug 、 Trazodone 、 Opiate 、 Pharmacology 、 Detoxification 、 Anesthesia 、 Naloxone 、 Medicine 、 Mianserin 、 Opioid withdrawal 、 Analysis of variance
摘要: The aims of this study were to evaluate the effects trazodone and mianserin on opioid-withdrawal symptoms in morphine-dependent mice. We used a comparative effect each drug withdrawal one model acutely high-dose mice, two models (high-dose lu-dose) chronically mice at Tel Aviv University Sackler School Medicine's laboratory.Trazodone, or both given together with high dose naloxone. Intensity was evaluated by tail-flick assay latencies three behavioural measurements (rearing, jumping grooming) group. Trazodone mianserin, separately,significantly attenuated all models. However, combined treatment not superior alone. combination has no additive value alone control opiate-dependent undergoing detoxification. When clinical settings, caution is needed order prevent unknown influence opioid-like drugs medication-assisted detoxification programmes if complete opiate aim.
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