The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats
作者： Anh Dzung Lê , Douglas Funk , Stephen Harding , Walter Juzytsch , Paul J. Fletcher
DOI: 10.1007/S00213-009-1481-Z
关键词: Clonidine 、 Receptor antagonist 、 Endocrinology 、 Pharmacology 、 Antagonist 、 Yohimbine 、 Agonist 、 Chemistry 、 Internal medicine 、 5-HT receptor 、 Oxidopamine 、 Self-administration
摘要: Rationale and objectives We previously showed that systemic administration of the prototypical alpha-2 noradrenaline (NA) receptor antagonist yohimbine increases alcohol self-administration reinstatement. Yohimbine also acts as an agonist 5-hydroxytryptamine (5-HT) 5-HT1A receptors, which have been shown to be involved in seeking. Here, we determined contributions properties its effects on
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