Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats
作者： AD Le , Douglas Funk , Kathleen Coen , Zhaoxia Li , Yavin Shaham
DOI: 10.1111/J.1369-1600.2011.00374.X
关键词: Raphe nuclei 、 Self-administration 、 Antagonist 、 Endocrinology 、 Psychology 、 Ethanol 、 Alcohol 、 Internal medicine 、 Yohimbine 、 Median raphe nucleus 、 Corticotropin-releasing hormone
摘要: The pharmacological stressor yohimbine increases ongoing alcohol self-administration and reinstates seeking in rats. This effect is attenuated by systemic injections of a corticotropin-releasing factor (CRF) antagonist. brain sites involved CRF's role yohimbine-induced taking are unknown. We report that the CRF receptor antagonist d-Phe into median raphe nucleus (MRN) reinstatement but had no on intake during self-administration. Results indicate an important MRN receptors not intake.
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