Acetylcholine turnover and aggression in related three strains of mice.

摘要: Abstract 1. This study compares brain levels of acetylcholine (ACh) and choline, ACh turnover in 3 inbred strains mice, CF-1, C57B1/6 By Balb-c-By; these parameters were measured control (aggregated) mice as well following two paradigms, mild footshock isolation, applied alone or combination. 2. Enzymic radioassay method was used to measure choline; evaluated by computation methods. 3. Aggregated Balb-c-By exhibited low choline compared those the other strains. CF-1 did not differ significantly; almost twofold higher than mice. 4. aggregated about twice high that more 5. The effects shock, shock combined with isolation on inconsistent and, frequently absent. 6. significantly decreased brains whether employed combination; there no additive effect when isolation. 7. change consistently after combination, case mice; some cases, increased. 8. Footshock proved be a inducer aggression strains; synergize respect Whether exposed combination procedures, aggressive 9. It is emphasized consistent facilitatory paradigms resulting from combining should contrasted turnover; altogether, data indicate related increased turnover.