Pharmaco-ethological analysis of agonistic behavior between resident and intruder mice: Effect of anticholinergic drugs.

摘要: The resident-intruder paradigm was employed in order to evoke an agonistic behavior mice. In this situation a resident male mouse has been cohabiting with female for 5 weeks, and intruder is introduced into the resident's home cage. A species-specific pattern of observed all significance cholinergic mechanisms mediation evaluated by pharmacological manipulations. Drugs were administered Scopolamine hydrobromide (0.25, 0.50 0.75 mg/kg, i.p.) significantly suppressed aggressive episodes (offensive sideways posture, tail rattling attack biting) dose-dependent manner, whereas peripheral anticholinergic drug methylscopolamine nitrate ineffective. On other hand, locomotor activity rearing response increased after administration scopolamine hydrobromide. evidence suggests that brain cholinoceptive may participate regulation intraspecies behavior. However, it appears nonspecific behavioral effects cannot be ruled out.