Pharmacological characterization of senktide-induced tail whips.
作者： Rebecca E. Nordquist , Theresa M. Ballard , Brigitte Algeyer , Meike Pauly-Evers , Laurence Ozmen
DOI: 10.1016/J.NEUROPHARM.2009.04.018
关键词:
摘要: Abstract The tachykinin NK3 receptor shows promise as a novel target for antipsychotics, but knowledge of downstream activity following activation is lacking. To determine the practical utility senktide-induced tail whips in mice tool determining and characterizing activation, were injected with 0.05 nmol senktide i.c.v. number whip bouts was counted 20 min. Strain differences observed, NMRI showing stronger response than C57Bl/6J mice. Tachykinin specificity confirmed by absence knockout Effects pharmacological agents tested pretreatment antagonists (SB222200, talnetant osanetant), which attenuated whips, NK1 antagonist MK869, had no effect on whips. Pharmacological interactions other neurotransmitter systems determined dopamine D1, D2, D3 antagonists, atypical serotonin 5HT1a 5HT2a/c benzodiazepine putative anxiolytics, antidepressants, an anticholinergic. Senktide-induced D2 unaffected drugs from classes. Thus, easily quantifiable, specific to receptor, provides valuable information pharmacology activation.
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