Forced unfolding of single-chain polymeric nanoparticles
作者： Nobuhiko Hosono , Aaron M. Kushner , Jaeyoon Chung , Anja R. A. Palmans , Zhibin Guan
DOI: 10.1021/JACS.5B02967
关键词: Supramolecular chemistry 、 Microscopy 、 Intramolecular force 、 Force spectroscopy 、 Chemistry 、 Folding (chemistry) 、 Nanoparticle 、 Polymer 、 Crystallography 、 Molecule
摘要: Atomic force microscopy (AFM)-based single-molecule spectroscopy (SMFS) is applied to single-chain polymeric nanoparticles (SCPNs) acquire information about the internal folding structure of SCPNs and inherent kinetic parameters supramolecular self-assembling motifs embedded into SCPNs. The used here are polyacrylate-based polymers carrying 2-ureido-4-[1H]-pyrimidinone (UPy) or benzene-1,3,5-tricarboxamide (BTA) pendants that induce an intramolecular chain collapse consisting one polymer only via cross-linking. SCPN stretched by AFM cantilever unfold mechanically, which allows measuring force–extension profiles Consecutive peaks observed in attributed rupture events self-assembled UPy/BTA units have been analyzed statistically for a series with different incorporation densities. results provide insights intern...
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