A Solvent-Based Strategy for Tuning the Internal Structure of Metallo-Folded Single-Chain Nanoparticles

摘要: Controlling the spatial distribution of catalytic sites in metallo-folded single-chain nanoparticles (SCNPs) is a first step toward rational design improved soft nano-objects. Here an unexplored pathway reported for tuning internal structure SCNPs. Unlike conventional SCNP synthesis good solvent (protocol I), proposed new route II) based on use amphiphilic random copolymers and transfer, after formation, from selective to (nonselective) conditions. The size morphology SCNPs obtained by two protocols, corresponding sites, have been determined combining results exclusion chromatography with triple detection, small-angle X-ray scattering molecular dynamics (MD) simulations. Remarkably, these protocols allows SCNPs, as supported MD simulations results. While protocol I yields homogeneous SCNP, are arranged into clusters case II.