Single Chain Polymeric Nanoparticles to Promote Selective Hydroxylation Reactions of Phenol Catalyzed by Copper

摘要: Metal-containing single chain polymeric nanoparticles (SCPNs) can be used as synthetic mimics of metalloenzymes. Currently, the role folded polymer backbones on activity and selectivity metal sites is not clear. Herein, we report our findings how frameworks modulate coordination Cu catalytic activity/selectivity Cu-containing SCPNs mimicking monophenol hydroxylation reactions. Imidazole-functionalized copolymers poly(methyl methacrylate-co-3-imidazolyl-2-hydroxy propyl methacrylate) were for intramolecular Cu-imidazole binding that triggered self-folding polymers. Polymer chains imposed steric hindrance which yielded unsaturated with an average number 3.3. showed a high reaction phenol to catechol, >80%, turnover frequency >870 h–1 at 60 °C. The was largely influenced by flexibility backbone where more flexible...