Construction and Self‐Assembly of Single‐Chain Polymer Nanoparticles via Coordination Association and Electrostatic Repulsion in Water

摘要: Simultaneous coordination-association and electrostatic-repulsion interactions play critical roles in the construction stabilization of enzymatic function metal centers water media. These are promising for self-assembly artificial aqueous polymer single-chain nanoparticles (SCNPs). Herein, dative-bonded SCNPs reported via simultaneous within single chains histamine-based hydrophilic block copolymer. The tunable through adjusting imidazolium/imidazole ratio response to pH, situ Cu(II)-coordination leads intramolecular association collapse acidic water. stabilized by electrostatic repulsion steric shielding nonionic water-soluble block, have a huge specific surface area accessible substrates Moreover, can assemble into micelles, networks, large particles programmably solution pH. unique media-sensitive phase-transformation behaviors provide general, facile, versatile platform fabrication enzyme-inspired smart catalysts.