Current therapeutic strategies for childhood hepatic malignant tumors.

摘要: The two main malignant hepatic tumors in children are hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). past decades have brought significant improvement to the outcomes of diagnosed with tumors, especially HBL, due improvements diagnosis treatment. Histological is essential for differential these tumors. In surgery, liver resection has become a safe secure technique because progress anatomical knowledge surgical dissection; also transplantation widely used unresectable Moreover, introduction effective chemotherapeutic regimens significantly improved survival HBL an increase number patients ultimately undergoing tumor resection, reduction incidence post-surgical recurrence. These result multicenter cooperative trials conducted by Japanese Study Group Pediatric Liver Tumor, Children’s Oncology Group, International Childhood Tumor Strategy including work German Association Hematology Oncology. This paper summarizes results studies calls on current international collaboration study called Hepatic Tumors Collaboration Project establish global clinical research childhood