Development of a Multiresidue Method for the Determination of 24 Pharmaceuticals in Clams by QuEChERS and Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry
作者： João Rodrigues , Stephanie Albino , Sofia Silva , Alexandra Cravo , Vitor Vale Cardoso
DOI: 10.1007/S12161-018-01418-Y
关键词: Quechers 、 Mass spectrometry 、 Wet weight 、 Chemistry 、 Human exposure 、 Tandem mass spectrometry 、 Chromatography 、 Triple quadrupole mass spectrometer 、 Linear range 、 Food science 、 Analytical chemistry 、 Applied Microbiology and Biotechnology 、 Safety Research 、 Safety, Risk, Reliability and Quality
摘要: Data on different therapeutic classes of pharmaceutical compounds (PhCs) in clams or other bivalves living natural conditions are scarce. The aim this work was the optimization and validation a method for determination PhCs further evaluation any potential human exposure risk due to their consumption. A quick, easy, cheap, effective, rugged, safe (QuEChERS) approach is proposed sample clean-up concentration 24 clams, with subsequent analysis by liquid chromatography-tandem mass spectrometry. This showed good linear range all coefficients (r2) between 0.9949 0.9993 variation (CVm) lower than 5.5%. allowed quantification target at trace levels (ng g−1), being most abundant PhC clam caffeine. detected more 70% samples concentrations ranging from 0.10 12 ng g−1 wet weight.
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