Effects of hysterectomy and uterine decidualization on in vivo levels of prostaglandins in the corpus luteum of adult pseudopregnant rats.
作者： Jan Olofsson , Ensio Norjavaara
DOI: 10.1095/BIOLREPROD43.5.762
关键词: Luteal phase 、 Endocrinology 、 Luteolysis 、 Decidualization 、 Hysterectomy 、 Internal medicine 、 Gestation 、 In vivo 、 Corpus luteum 、 Biology 、 Uterus
摘要: A possible role of the uterus in regulating Content luteal prostaglandins (P65) was investigated. Pseudopregnancy Induced adult virgin female rats by mating them with vasectomized male rats. On Day 5 pseudopregnancy, decidualization induced or hysterectomy performed. As controls, Intact pseudopregnant animals a lutcal phase 13 ± 1 days were used. Measurements vivo tissue levels PGF�., POES, and 6-keto-PGF1,� performed RIA after homogenization extraction procedures CL pseudopregnancy remainder ovaries on Days 5, 13, 19. Serum progesterone 20u.dihydroprogesterone determined RIA. In hysterectomized animals, PGFa. Increased 2.5-fold corpora lutea Compared but still lower than control undergoing functional luteolysis 13. Decidual-tissue.bearing exhibited low PGF,,, pseudopregnancy. 19, when had occurred decidual.tissue.
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