Administration of L-3,4-dihydroxyphenylalanine to rats after complete hepatectomy-I. Metabolites in tissues.
作者： Gertrude M. Tyce , Charles A. Owen
DOI: 10.1016/0006-2952(79)90121-7
关键词: Amine oxidase 、 Metabolism 、 Internal medicine 、 Monoamine oxidase 、 Endocrinology 、 Biology 、 Gastrointestinal tract 、 Dopamine 、 Kidney 、 Norepinephrine 、 Dihydroxyphenylalanine
摘要: Abstract 14 C-Labeled l -3,4-dihydroxyphenylalanine ( -DOPA, 20 μCi, 11 mg/kg) was injected intravenously into control rats and after complete hepatectomy. The were killed min, studies made of the disposition metabolism -[ C]DOPA in plasma, erythrocytes, brain, heart, kidney, gastrointestinal tract, spleen, lung, adrenals, muscle, pancreas liver (of controls). Total C these tissues accounted for 31 per cent dose 53 operated animals. hepatectomized that contained a disproportionately high amount radioactivity heart erythrocytes. Amounts [ C]dopamine higher than animals found most especially kidneys, although there evidence decarboxylation DOPA inhibited Further to norepinephrine limited rats; associated with 3,4-dihydroxyphenylacetic acid. This suggests hepatectomy is an impairment vesicular uptake or retention dopamine inhibition β-hydroxylation. As result, formed metabolized by mitochondrial monoamine oxidase [amine (flavincontaining) EC 1.4.3.4] form There little
elsevier.com
sci-hub.se 参考文章(32)
WH Oldendorf, Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection American Journal of Physiology. ,vol. 221, pp. 1629- 1639 ,(1971) , 10.1152/AJPLEGACY.1971.221.6.1629
Gertrude M. Tyce, Charles A. Owen, Administration of l-3,4-dihydroxyphenylalanine to rats after complete hepatectomy—II: Excretion of metabolites Biochemical Pharmacology. ,vol. 28, pp. 3279- 3284 ,(1979) , 10.1016/0006-2952(79)90122-9
J I Routh, R E Bannow, R W Fincham, J L Stoll, Excretion of L-Dopa and Its Metabolites in Urine of Parkinson's Disease Patients Receiving L-Dopa Therapy Clinical Chemistry. ,vol. 17, pp. 867- 871 ,(1971) , 10.1093/CLINCHEM/17.9.867
Lewis Landsberg, Martha Beh Berardino, Patricio Silva, Metabolism of 3H-l-dopa by the rat gut in vivo—evidence for glucuronide conjugation Biochemical Pharmacology. ,vol. 24, pp. 1167- 1174 ,(1975) , 10.1016/0006-2952(75)90057-X
Peter T Mearrick, Garry G Graham, Denis N Wade, None, The role of the liver in the clearance ofl-dopa from plasma Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 3, pp. 13- 23 ,(1975) , 10.1007/BF01066592
Gertrude M. Tyce, Eunice V. Flock, Charles A. Owen, George H.C. Stobie, Claude David, 5-Hydroxyindole metabolism in the brain after hepatectomy Biochemical Pharmacology. ,vol. 16, pp. 979- 992 ,(1967) , 10.1016/0006-2952(67)90270-5
Lewis Landsberg, Howard L. Taubin, Uptake and metabolism of l-3,4-dihydroxyphenylalanine (dopa) in rat tissues Biochemical Pharmacology. ,vol. 22, pp. 2789- 2800 ,(1973) , 10.1016/0006-2952(73)90146-9
M. Scheulen, P. Wollenberg, H.M. Bolt, H. Kappus, H. Remmer, Irreversible binding of DOPA and dopamine metabolites to protein by rat liver microsomes. Biochemical and Biophysical Research Communications. ,vol. 66, pp. 1396- 1400 ,(1975) , 10.1016/0006-291X(75)90514-8
Eunice V. Flock, Gertrude M. Tyce, Charles A. Owen, Utilization of [U-14C]glucose in brain after total hepatectomy in the rat. Journal of Neurochemistry. ,vol. 13, pp. 1389- 1406 ,(1966) , 10.1111/J.1471-4159.1966.TB04301.X
Benjamin Weiss, G. Victor Rossi, Metabolism of dopa-14C in the normal and α-methyldopa-treated mouse Biochemical Pharmacology. ,vol. 12, pp. 1399- 1405 ,(1963) , 10.1016/0006-2952(63)90209-0