Do histological, immunohistochemical, and metabolic (radioiodine and fluorodeoxyglucose uptakes) patterns of metastatic thyroid cancer correlate with patient outcome?

摘要: The aim of this study is to search for relationships between histology, radioiodine ((131)I) uptake, fluorodeoxyglucose (FDG) and disease outcome in patients with metastatic thyroid cancer. Eighty cancer (34 males, 46 females, mean age at the time diagnosis metastases: 55 years) were retrospectively studied. All treated radioactive iodine evaluated by FDG-positron emission tomography (PET). Primary tumor tissue sample was available all cases. Forty-five (56%) had a papillary, 12 (15%) follicular, 23 (29%) poorly differentiated Cellular atypias, necrosis, mitoses, capsule infiltration, vascular invasion frequently detected (70, 44, 52, 60, 71% respectively). Metastases disclosed FDG uptake 58 (72%) (131)I 37 (45%). only significant prognostic factor survival (P=0.02). maximum standardized value number avid lesions also related prognosis (P=0.03 0.009). Age metastases (P=0.001) presence necrosis (P=0.002) independent predictive factors uptake. Radioiodine stable progressive 1 year (P=0.001). Histological subtype not correlated vivo metabolism prognosis. In conclusion, highly survival. alone does correlate (131)I/FDG pattern patient outcome. Well-differentiated presenting histological features such as on PET scan should be considered aggressive cancers.