The Biology of Caspases
作者： Tasman James Daish , Sharad Kumar
DOI: 10.1007/978-1-59745-199-4_17
关键词: Caspase 、 Transcription (biology) 、 Apoptosis 、 Cell biology 、 Biology 、 Programmed cell death 、 Proteases 、 Function (biology)
摘要: Programmed cell death (PCD) is a vital part of the normal development metazoans. PCD requires conserved class cysteine proteases, termed caspases, to affect controlled demise cells. When regulatory pathways controlling are perturbed through mutation, disease states, including cancers and neurodegenerative disorders, can occur. Therefore, caspases molecules regulating their function potential candidates for therapeutic targets. This chapter describes caspase structure, regulation, in context biological specific roles they play protection living systems. A section also dedicated emerging field concerning nonapoptotic functions “apoptotic” development.
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