Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification

摘要: Pancreatic cancer is one of the most lethal all cancers. The median survival 6 months, and less than 5% those diagnosed survive 5-years. Recurrent genetic deletions amplifications in 73 pancreatic adenocarcinomas, largest sample set analyzed to date for cancer, were defined using comparative genomic hybridization recurrent alterations identified target a number previously well-characterized genes, as well regions that contain possible new oncogenes tumor suppressor genes. We have focused on chromosome 19q13, region frequently found amplified demonstrate how boundaries common mutation can be mapped, gene, this case PAK4 chromosome19q13, functionally validated. show although gene not activated by cell lines with amplification, an oncogenic form KRAS2 present these cells, activate PAK4. In fact three ...