p21-activated kinase family: promising new drug targets

Helen King, Nicole S Nicholas, Claire M Wells, None, Role of p-21-Activated Kinases in Cancer Progression International Review of Cell and Molecular Biology. ,vol. 309, pp. 347- 387 ,(2014) , 10.1016/B978-0-12-800255-1.00007-7

A Levitzki, E Manser, H Maruta, H He, L Lim, Y Hirokawa, Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer Journal. ,vol. 7, pp. 191- 202 ,(2001)

Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, Weiru Wang, Inhibitors of p21-activated kinases (PAKs). Journal of Medicinal Chemistry. ,vol. 58, pp. 111- 129 ,(2015) , 10.1021/JM501613Q

David C. Edwards, Luraynne C. Sanders, Gary M. Bokoch, Gordon N. Gill, Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nature Cell Biology. ,vol. 1, pp. 253- 259 ,(1999) , 10.1038/12963

Quanwen Li, Stefanie Roshy Mullins, Bonnie F. Sloane, Raymond R. Mattingly, p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia. ,vol. 10, pp. 314- 329 ,(2008) , 10.1593/NEO.07970

Alastair J. King, Huaiyu Sun, Bruce Diaz, Darlene Barnard, Wenyan Miao, Shubha Bagrodia, Mark S. Marshall, The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 Nature. ,vol. 396, pp. 180- 183 ,(1998) , 10.1038/24184

Gary M. Bokoch, Thomas Rudel, Tsung-Hsien Chuang, Frank T. Zenke, Cutting Edge: p21-Activated Kinase (PAK) Is Required for Fas-Induced JNK Activation in Jurkat Cells Journal of Immunology. ,vol. 160, pp. 7- 11 ,(1998)

Nerina Gnesutta, Jian Qu, Audrey Minden, The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis Journal of Biological Chemistry. ,vol. 276, pp. 14414- 14419 ,(2001) , 10.1074/JBC.M011046200

Jean Benhattar, Lorena Losi, Pascal Chaubert, Jean-Claude Givel, Jose Costa, Prognostic significance of K-ras mutations in colorectal carcinoma Gastroenterology. ,vol. 104, pp. 1044- 1048 ,(1993) , 10.1016/0016-5085(93)90272-E

Hong He, Nhi Huynh, Kevin H. Liu, Cathy Malcontenti-Wilson, Jin Zhu, Christopher Christophi, Arthur Shulkes, Graham S. Baldwin, P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth. Cancer Letters. ,vol. 317, pp. 65- 71 ,(2012) , 10.1016/J.CANLET.2011.11.014