The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

作者: Alastair J. King , Huaiyu Sun , Bruce Diaz , Darlene Barnard , Wenyan Miao

DOI: 10.1038/24184

关键词:

摘要: … present studying the ability of Pak1 to phosphorylate and regulate Raf-1… of rat-1 fibroblasts by oncogenic Ras 14 . We also predict potential regulation of all three mammalian isoforms of …

参考文章(43)
R. Marais, Y. Light, H.F. Paterson, C.J. Marshall, Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal. ,vol. 14, pp. 3136- 3145 ,(1995) , 10.1002/J.1460-2075.1995.TB07316.X
Gisela Heidecker, Walter Kölch, Deborah K. Morrison, Ulf R. Rapp, The role of Raf-1 phosphorylation in signal transduction. Advances in Cancer Research. ,vol. 58, pp. 53- 73 ,(1992) , 10.1016/S0065-230X(08)60290-0
William J. Boyle, Peter van der Geer, Tony Hunter, Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods in Enzymology. ,vol. 201, pp. 110- 149 ,(1991) , 10.1016/0076-6879(91)01013-R
T.S. Chao, D.A. Foster, U.R. Rapp, M.R. Rosner, Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. Journal of Biological Chemistry. ,vol. 269, pp. 7337- 7341 ,(1994) , 10.1016/S0021-9258(17)37289-7
Joseph C. Kolars, Patrick Benedict, Phyllissa Schmiedlin-Ren, Paul B. Watkins, Aflatoxin B1-adduct formation in rat and human small bowel enterocytes Gastroenterology. ,vol. 106, pp. 433- 439 ,(1994) , 10.1016/0016-5085(94)90602-5
D F Jelinek, S Andersson, C A Slaughter, D W Russell, Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. Journal of Biological Chemistry. ,vol. 265, pp. 8190- 8197 ,(1990) , 10.1016/S0021-9258(19)39056-8
B Diaz, D Barnard, A Filson, S MacDonald, A King, M Marshall, PHOSPHORYLATION OF RAF-1 SERINE 338-SERINE 339 IS AN ESSENTIAL REGULATORY EVENT FOR RAS-DEPENDENT ACTIVATION AND BIOLOGICAL SIGNALING Molecular and Cellular Biology. ,vol. 17, pp. 4509- 4516 ,(1997) , 10.1128/MCB.17.8.4509
Hisashi HASHIMOTO, Kenji TOIDE, Ryuji KITAMURA, Masako FUJITA, Sanae TAGAWA, Susumu ITOH, Tetsuya KAMATAKI, Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control. FEBS Journal. ,vol. 218, pp. 585- 595 ,(1993) , 10.1111/J.1432-1033.1993.TB18412.X