Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages

作者: R. Gallily , A. Yamin , R.R. Caspi , R.R. Avtalion

DOI: 10.1016/S0145-305X(82)80043-8

关键词: BiologyLymphoblastIn vitroImmunologyMicrobiologyAdipose tissue macrophagesCell cultureCyprinusFish <Actinopterygii>Developmental biology

摘要: Abstract Non-immune non-activated murine peritoneal macrophages killed in vitro fish ( Cyprinus carpio ) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited thioglycollate-elicited as well depleted lymphocytes. It is suggested that mammalian have a xenolytic potential towards phylogenetically distant species which analogous capacity invertebrate phagocytes destroy xenografts.

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