The effect of the putative AT2 agonist, p‐aminophenylalanine6 angiotensin II, on thirst and sodium appetite in rats

摘要: Intracerebroventricular injection of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II (p-NH2Phe6-Ang II), caused dose-dependent increases in intakes water and NaCl similar to those produced by but requiring more than one thousand times dose. Very large doses another angiotensin(1-7) heptapeptide (Ang(1-7)), had no effect on up 24 h after injection, nor did Ang(1-7) affect II-induced drinking when two peptides were given together. The AT1 antagonist, losartan, not CGP 42112B, inhibited p-NH2Phe6-Ang II- drinking, suggesting that II, like acts receptors. However, PD 123319, response both dipsogens. Since unaffected this could mean there are different receptor subtypes which only 123319-sensitive is involved drinking. But because very 123319 used it also likely was loss specificity resulting cross-reaction with results do favour involvement receptors angiotensin-induced thirst sodium appetite short term.