Tandem repeats in the CpG islands of imprinted genes.

摘要: In contrast to most genes in mammalian genomes, imprinted are monoallelically expressed depending on the parental origin of alleles. Imprinted gene expression is regulated by distinct DNA elements that exhibit allele-specific epigenetic modifications, such as methylation. These so-called differentially methylated regions frequently overlap with CpG islands. Thus, islands may contain special distinguish them from biallelically genes. Here, we present a detailed study mouse and human. Our shows more tandem repeat arrays their than randomly selected both species. addition, possess intragenic serve promoters antisense transcripts. This feature much less pronounced human, indicating an interspecies variability evolution imprinting control elements.