The 52K cathepsin-D of breast cancer: structure, regulation, function and clinical value
作者： Henri Rochefort , Patrick Augereau , Françoise Capony , Marcel Garcia , Vincent Cavailles
DOI: 10.1007/978-1-4613-1733-3_9
关键词: Internal medicine 、 Oncology 、 Estrogen 、 Cancer research 、 Metastasis 、 Cell growth 、 Progesterone receptor 、 Estrogen receptor 、 Cancer cell 、 Breast cancer 、 Cathepsin D 、 Biology
摘要: A major question in cancer research is: why do cells continuously proliferate and invade adjacent tissue. Breast are particularly suitable for studying this since when they differentiated, contain estrogen receptors, estrogen, specifically, triggers their growth. One approach to understanding the estrogen-induced growth stimulation model is identify factors involved control of cell proliferation [1–6]. Here, we illustrate a study regulation MCF7 by which found secreted 52K protein with mitogenic activity. It was identified as protease that also possibly process tumor metastasis.
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