p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome.

摘要: Gastrointestinal stromal tumors (GISTs) are characterized by alterations in genes involved cell cycle regulation. Although p16 (INK4A) have been extensively investigated GISTs, there still discrepancies regarding its prognostic value. Therefore, we evaluated the clinical occurrence, diagnostic and value of staining GIST. One hundred one patients (54 women 47 men) with a mean age 64.1 years (range, 17–94 years) were surgically treated for GIST within 10-year period. Of these patients, 28 (28%) affected metastases (mean follow-up, 4.5 years). In 36 (36%), occurred coincidentally other malignancies. Expression c-kit was confirmed 97 (96%). high-risk GIST, expression highly predictive poor prognosis, i.e., development recurrence or (P = .006) survival .004). addition, reduction who .041). The disease-specific disease-free 1-, 3-, 5-year rate 96%, 90%, 85% 81%, 77%, 72%, respectively. Primary tumor state, size, classification as relevant predictors unfavorable prognosis < .001). Our results indicate that metastases, is outcome. Thus, addition to classification, might be an indicator “very high risk GIST.”