Noise Minimization in Eukaryotic Gene Expression

摘要: All organisms have elaborate mechanisms to control rates of protein production. However, production is also subject stochastic fluctuations, or noise. Several recent studies in Saccharomyces cerevisiae and Escherichia coli investigated the relationship between transcription translation fluctuations levels, more generally, how such randomness a function intrinsic extrinsic factors. fundamental question whether stochasticity expression generally biologically relevant has not been addressed, it remains unknown random noise rate most genes significantly affects fitness any organism. We propose that should be particularly sensitive variation levels two classes genes: whose deletion lethal organism encode subunits multiprotein complexes. Using an experimentally verified model gene S. cerevisiae, we estimate for nearly every yeast gene, confirm our prediction essential complex-forming proteins involves lower than does other genes. Our results support hypothesis important variable, detrimental organismal fitness, natural selection.