ErbB signaling has a role in radial sorting independent of Schwann cell number

摘要: In the peripheral nervous system, Schwann cells make myelin, a specialized sheath that is essential for rapid axonal conduction of action potentials. Immature initially interact with many axons, but, through process termed radial sorting, eventually one segment single axon as promyelinating cells. Previous studies have identified genes are required cell extension and proliferation during sorting. analyses also show ErbB signaling proliferation, myelination, proper formation unmyelinated Remak bundles. Because both we sought to determine if primary function in this regulate or controls other aspects To address question, applied small molecule inhibitors vivo zebrafish independently block proliferation. Ultrastructural analysis treated animals revealed sorting vivo. signaling, however, extension, while not. These results provide evidence plays direct role addition its regulating