New insights into signaling during myelination in zebrafish.

摘要: Myelin is a vertebrate adaptation that allows for the rapid propagation of action potentials along axons. Specialized glial cells-oligodendrocytes in central nervous system (CNS) and Schwann cells peripheral (PNS)-form myelin by repeatedly wrapping axon segments. Debilitating diseases result from disruption myelin, including multiple sclerosis Charcot-Marie-Tooth neuropathies. The process myelination involves extensive communication between associated neurons. past few years have seen important progress understanding molecular basis signals coordinate development these fascinating cells. This review highlights recent advances deriving studies zebrafish model system, with primary focus on PNS. While Neuregulin1-ErbB signaling has long been known to play roles development, work elucidated its cell migration radial sorting axons vivo. Forward genetic screens also uncovered new genes required myelinated axons, gpr126, which encodes G-protein coupled receptor beyond promyelinating stage. In addition, themselves, regulating boundary PNS CNS positioning nerve after initial outgrowth.