In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration

摘要: The myelin sheath insulates neuronal axons and markedly increases the nerve conduction velocity. In peripheral nervous system (PNS), Schwann cell precursors migrate along embryonic to their final destinations, where they eventually wrap around individual form after birth. ErbB2 ErbB3 tyrosine kinase receptors a heterodimer are extensively expressed in lineage cells. ErbB2/3 is thought be one of primary regulators controlling entire development. bona fide receptor for ligand neuregulin-1. Although well known regulate both precursor migration myelination by cells fishes, it still remains unclear whether mammals, actually regulates migration. Here, we show that knockdown using cell-specific promoter mice causes delayed precursors. contrast, littermate control display normal Similar results seen an vitro assay reaggregated Also, reduces thickness sciatic nerves, consistent with established role myelination. Thus, plays key migration, as myelination, mouse cells, presenting genetically conservative