Recent Insights into Molecular Mechanisms That Control Growth Factor Receptor-Mediated Schwann Cell Morphological Changes During Development

摘要: Rapid progress in molecular biological techniques, especially for gene modification technologies as well RNA technologies, allows us to investigate how Schwann cells differentiate and myelinate axons at vitro vivo levels, the same rate until an experimental conclusion is reached. Through a middle embryonic stage after birth, cell myelination processes are categorized into three stages: migration, elongation along axons, axonal myelination. However, these stages not independent of each other but series continuous processes. Herein, we review recent unique, intracellular mechanisms focusing on growth factor receptor-mediated morphological changes throughout processes, possibly identifying one basic mechanism forming morphology. Such studies also provide basis understanding human pathological states arise.