The Biology of Long Non-Coding RNA

摘要: The majority of human transcribed loci do not encode protein. Long non-coding RNAs (lncRNAs) are an emerging class RNA that implicated in the regulation gene expression at almost every level. Although their mechanisms action relatively unknown, general mechanistic themes emerging. They have ability to affect through a spectrum interactions with RNA, proteins and possibly DNA. With capacity act both cis trans, they can guide epigenetic-modifier complexes or transcription factors particular genomic sites. These lncRNAs been variety cellular processes, including chromatin modification, imprinting cell cycle regulation. This chapter examines biology, conservation, function roles disease as well various approaches characterisation.