The link between long noncoding RNAs and depression.

摘要: The major depressive disorder (MDD) is a relatively common mental from which that hundreds of million people have suffered, leading to displeasing life quality, characterized by health damage and even suicidal thoughts. complicated development functioning MDD still under exploration. Long noncoding RNA (lncRNAs) are highly expressed in the brain, could affect neural stem cell maintenance, neurogenesis gliogenesis, brain patterning, synaptic stress responses, plasticity. dysregulation certain lncRNAs induces neurodevelopmental, neurodegenerative neuroimmunological disorders, primary tumors, psychiatric diseases. Although advances been made, no fully satisfactory treatments for depression available, further investigation requested. And recently data showed expression level majority demonstrated clear tendency upregulation, dysregulated miRNAs proved co-synergism mechanism, why we speculate lncRNA might get capability regulate MDD. Few identified deeply studied detailed experiments up until now, little predictions their function raised, researches calling discover signal pathway related regulatory networks.