Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node
作者： Yun Sun , Mengxiao Yu , Sheng Liang , Yingjian Zhang , Chenguang Li
DOI: 10.1016/J.BIOMATERIALS.2011.01.011
关键词: Fluorine 、 Nanotechnology 、 Photoluminescence 、 Pet imaging 、 Rare earth 、 Positron emission tomography 、 Nanoparticle 、 Upconversion luminescence 、 Sentinel lymph node 、 Nuclear medicine 、 Materials science 、 Biophysics 、 Mechanics of Materials 、 Bioengineering 、 Biomaterials 、 Ceramics and Composites
摘要: Rare-earth-based nanoparticles have attracted increasing attention for their unique optical and magnetic properties. However, application in bioimaging has been limited to photoluminescence resonance imaging. To facilitate use other techniques, we developed a simple, rapid, efficient general synthesis strategy (18)F-labeled rare-earth through facile inorganic reaction between cations fluoride ions. The (18)F-labeling process based on elements was achieved efficiently water at room temperature with an yield of >90% completed within 5 min, only simple purification by aqueous washing centrifugation, without the organic agents. effectiveness further evaluated positron emission tomography (PET) imaging vivo distribution lymph monitoring. In addition, this is proposed creation dual-model technique, combining upconversion luminescence PET
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