The pathogenesis of Kawasaki disease and superantigens.

摘要: Kawasaki disease (KD) is an acute febrile illness in infants and children with systemic clinical symptoms, including coronary artery aneurysms. Findings seen KD patients such as infiltration of T cells into vascular lesions, elevation soluble interleukin 2 receptors serum, imbalance cell subsets, transient depletion CD11/CD18 suggest that the activation involved pathogenesis KD. In 1992, interesting mechanism was proposed which by a certain superantigen Examinations have been undertaken extensively to confirm hypothesis. We, however, still do not reliable evidence supporting above present paper we review research papers support or rule out view described above. addition, discuss relation between Yersinia pseudotuberculosis infection manifests symptoms quite similar those