Radiogenomic analysis of breast cancer using MRI: a preliminary study to define the landscape.
作者： Shota Yamamoto , Daniel D. Maki , Ronald L. Korn , Michael D. Kuo
DOI: 10.2214/AJR.11.7824
关键词: Oncology 、 Gene sets 、 Gene expression profiling 、 Radiogenomics 、 Medicine 、 Pathology 、 Breast cancer 、 Imaging data 、 Genomics 、 Magnetic resonance imaging 、 Breast MRI 、 Internal medicine
摘要: OBJECTIVE. Molecular profiling studies have defined the increasing importance of gene expression phenotyping in breast cancer. However, relationship between global transcriptomic profiles and information provided by MRI remains to be examined. In this pilot study, our aim was provide a preliminary radiogenomic association map linking MR image phenotypes underlying patterns MATERIALS AND METHODS. From multiinstitutional total 353 patients with diagnosis cancer were examined for analysis. Radiogenomic analysis then performed on subset these (n = 10) who also underwent MRI. Two radiologists evaluated each study across 26 predefined imaging phenotypes. Analyses correlate data define associations specific sets interest. RESULTS. High-level revealed 21 traits that glob...
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