International investigation of breast MRI: results of a multicentre study (11 sites) concerning diagnostic parameters for contrast-enhanced MRI based on 519 histopathologically correlated lesions

摘要: A multicentre study was undertaken to provide fundamentals for improved standardization and optimized interpretation guidelines of dynamic contrast-enhanced MRI. Only patients scheduled biopsy a clinical or imaging abnormality were included. They underwent standardized MRI on Siemens 1.0 (163 valid lesions ≥ 5 mm) 1.5 T (395 using 3D fast low-angle shot (FLASH; 87 s) before five times after bolus 0.2 mmol Gd-DTPA/kg. One-Tesla data analysed separately discriminant analysis. histologically correlated entered the statistical evaluation. Histopathology in retrospect open. The best results achieved by combining up wash-in wash-out parameters. Different weighting false-negative vs false-positive calls allowed formulation statistically based scheme yielding rules highest possible sensitivity (specificity 30 %), moderate (50 %) high (64–71 specificity. sensitivities obtained at above specificity levels better (98, 97, 96 than (96, 93, 86 %). Using widely available MR technique definition founded is possible. Choice an optimum rule may vary with question. Prospective testing remains necessary. Differences are not significant but be due pulse sequences