The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway"
作者： Michel Félétou
DOI:
关键词: Biophysics 、 Chemistry 、 Internal medicine 、 Membrane potential 、 Vascular smooth muscle 、 Hyperpolarization (biology) 、 Cardiac action potential 、 Endocrinology 、 Potassium channel 、 BK channel 、 Voltage-dependent calcium channel 、 Endothelium
摘要: ABSTRACT The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in intracellular Ca₂⁺ concentration followed opening Ca₂⁺-activated K⁺ channels small intermediate conductances (SKCa IKCa). show a distinct subcellular distribution, suggesting that their activation could be elicited stimuli. Following KCa activation, can conducted underlying electrical coupling through myo-endothelial gap junctions. In addition, potassium efflux lead accumulation ions intercellular space subsequent Kir2.1 and/or Na⁺/K⁺-ATPase. ...
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