Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis.

摘要: Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic, curved bacillus that specifically colonizes the gastric mucosa. The interaction between virulence factors, host genetic factors and environmental contributes to pathogenesis of H. pylori, such as atrophic gastritis intestinal metaplasia. Infection with has recently been recognized strongest risk factor for cancer. As pleiotropic cytokine, transforming growth (TGF)-β regulates various biological processes, ranging from cell cycle, proliferation, apoptosis, metastasis. Recent studies have shed new light on involvement TGF-β signaling in pylori. This review focuses potential etiologic role pylori-mediated pathogenesis.