Th17 Cells in Cancer: The Ultimate Identity Crisis
作者： Stefanie R. Bailey , Michelle H. Nelson , Richard A. Himes , Zihai Li , Shikhar Mehrotra
关键词:
摘要: Th17 cells play a complex and controversial role in tumor immunity have been found to exhibit fluctuating identity within the context of cancer. The recent, expanding literature on these attests their puzzling nature, either promoting or suppressing growth depending malignancy course therapeutic intervention investigated. This review addresses several newly appreciated factors that may help delineate cells’ immunological properties Several reports suggest inflammatory signals induced milieu regulate functional fate antitumor activity cells. Recent findings also point significant alterations due interplay with regulatory T lymphocytes cytotoxic CD8+ microenvironment. Finally, an appreciation for stem cell-like augment persistence emerges from recent reports. impact efficacy how be exploited improve cancer therapies will discussed.
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Sarah Sherlock, Zhuang Liu, Qizhen Cao, Hongjie Dai, Xiaoyuan Chen, Corrine Davis, Kai Chen, Drug delivery with carbon nanotubes for in vivo cancer treatment arXiv: Materials Science. ,(2008) , 10.1158/0008-5472
Matthew L. Albert, Birthe Sauter, Nina Bhardwaj, Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs Nature. ,vol. 392, pp. 86- 89 ,(1998) , 10.1038/32183
Gretta L. Stritesky, Norman Yeh, Mark H. Kaplan, IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage Journal of Immunology. ,vol. 181, pp. 5948- 5955 ,(2008) , 10.4049/JIMMUNOL.181.9.5948
Yunjuan Zhao, Lin Yang, Xiangbing Wang, Zhiguang Zhou, The new insights from DPP-4 inhibitors: their potential immune modulatory function in autoimmune diabetes. Diabetes-metabolism Research and Reviews. ,vol. 30, pp. 646- 653 ,(2014) , 10.1002/DMRR.2530
Lisa M. Coussens, Zena Werb, Inflammation and cancer Nature. ,vol. 420, pp. 860- 867 ,(2002) , 10.1038/NATURE01322
Jinfang Zhu, William E. Paul, CD4 T cells: fates, functions, and faults Blood. ,vol. 112, pp. 1557- 1569 ,(2008) , 10.1182/BLOOD-2008-05-078154
Ilona Kryczek, Mousumi Banerjee, Pui Cheng, Linhua Vatan, Wojciech Szeliga, Shuang Wei, Emina Huang, Emily Finlayson, Diane Simeone, Theodore H. Welling, Alfred Chang, George Coukos, Rebecca Liu, Weiping Zou, Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments Blood. ,vol. 114, pp. 1141- 1149 ,(2009) , 10.1182/BLOOD-2009-03-208249
Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, Richard G. Carroll, Gwendolyn K. Binder, David Teachey, Minu Samanta, Mehdi Lakhal, Brian Gloss, Gwenn Danet-Desnoyers, Dario Campana, James L. Riley, Stephan A. Grupp, Carl H. June, Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo Molecular Therapy. ,vol. 17, pp. 1453- 1464 ,(2009) , 10.1038/MT.2009.83
Donggou He, Hui Li, Nabiha Yusuf, Craig A. Elmets, Mohammad Athar, Santosh K. Katiyar, Hui Xu, IL-17 Mediated Inflammation Promotes Tumor Growth and Progression in the Skin PLoS ONE. ,vol. 7, pp. e32126- ,(2012) , 10.1371/JOURNAL.PONE.0032126
Lin Wang, Tangsheng Yi, Wang Zhang, Drew M. Pardoll, Hua Yu, IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer Cancer Research. ,vol. 70, pp. 10112- 10120 ,(2010) , 10.1158/0008-5472.CAN-10-0775