Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

摘要: Th17 cells play an active role in autoimmune diseases. However, the nature of is poorly understood cancer patients. We studied cells, associated mechanisms, and clinical significance 201 ovarian Tumor-infiltrating exhibit a polyfunctional effector T-cell phenotype, are positively with negatively tumor-infiltrating regulatory T cells. Tumor-associated macrophages promote through interleukin-1β (IL-1β), whereas inhibit adenosinergic pathway. Furthermore, synergistic action between IL-17 interferon-γ, stimulate CXCL9 CXCL10 production to recruit tumor microenvironment. The levels ascites reduced more advanced diseases predict patient outcome. Altogether, may contribute protective human immunity inducing Th1-type chemokines recruiting Inhibition represents novel immune evasion mechanism. This study thus provides scientific rationale for developing immune-boosting strategies based on promoting cell population