Role of platelet derived growth factor receptor (PDGFR) over-expression and angiogenesis in ependymoma.

摘要: New molecularly targeted therapies are needed for childhood ependymoma. Angiogenesis and the PDGFR pathway could be potential therapeutic targets. This study aimed to screen ependymomas expression clinicopathological correlates of angiogenic factors targets including VEGFR, endoglin (CD105), CD34, CD31, c-Kit, PDGFR-α PDGFR-β. Immunohistochemistry angiogenesis β was performed in 24 archival tumor samples from children adults treated ependymoma at our institution. CD31 density, CD105 density pericyte coverage index (PCI) were calculated. These findings correlated with clinical outcome. VEGFR2 overexpressed cells only one out cases, but found vessels 6 cases. over-expressed seven cases (29.2 %). PCI did not correlate PDGFRs. Overexpression overexpression endothelium had prognostic significance this maintained multivariate analysis (2 year progression free survival 16.7 ± 15.2 vs. 74.5 those low/no expression, hazard ratio = 5.78, p 0.04). A number expressed endothelium. Preliminary evidence suggests that PDGFRs have a data should further evaluated as using novel inhibitors.