Tumor vessel biology in pediatric intracranial ependymoma Clinical article

摘要: Object This study aimed to characterize the pediatric intracranial ependymoma vasculature in terms of angiogenic activity and maturation status so as provide indications for applicability vessel-targeted therapy cases ependymoma. Methods Tumor samples obtained patients with ependymomas were immunohistochemically (double) stained Ki 67/CD34, caspase 3a/CD34, vascular endothelial growth factor (VEGF)–A, –B, –C, –D, collagen Type IV, smooth muscle actin determine microvessel density, tumor cell proliferation apoptotic fraction, relative expression VEGF family members, coverage cells by basal membrane pericytes. Messenger RNA angiopoietin-1 -2 was analyzed real-time reverse transcriptase polymerase chain reaction. These data compared those a glioblastoma series. Results Despite low turnover, density was...