Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer

摘要: Vascular endothelial growth factor (VEGF) may affect the phenotype of cancer cells, such as velocity and metastatic potential, due to its probable multifunctional property including a mitogenic activity for vascular cells. The present study was designed investigate association VEGF mRNA expression with progression metastasis human colorectal cancer. level quantified by Northern blot hybridization in tumorous non-tumorous tissues obtained from 60 primary patients. ratio former latter defined T/N ratio, prognostic significance this following surgery, addition relationship evaluated. value significantly correlated depth tumour infiltration (P=0.046), incidence liver (P < 0.0001) lymph node (P=0.036). Patient prognosis estimated Kaplan-Meier method log-rank test. When higher than 4.8 which chi2 test maximal, showing overexpression mRNA. Patients demonstrated poorer survival patients without 0.001). overall hazard death 1.94 according multivariate analysis (P=0.005). Thus, is associated progression, invasion cancer, assumed be closely poor Moreover, used an independent marker