The influence of paediatric HIV infection on circulating B cell subsets and CXCR5(+) T helper cells.
作者： A. Bamford , M. Hart , H. Lyall , D. Goldblatt , P. Kelleher
DOI: 10.1111/CEI.12618
关键词: T cell 、 T helper cell 、 Virology 、 CXCR5 、 Humoral immunity 、 Memory B cell 、 B cell 、 Immune system 、 Lymphocyte 、 Biology 、 Immunology
摘要: Antiretroviral therapy (ART) only partially restores HIV-induced alterations in lymphocyte populations. We assessed B and T cell phenotypes a cohort of children from single centre the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority infected (44 56) were on fully suppressive combination ART. Children had significantly lower memory CD4(+) CD45RO(+) CXCR5(+) [follicular helper (Tfh)-like] percentages. Detectable viraemia was associated higher CD21(-) (activated exhausted/tissue-like memory) cells. A greater proportion life spent ART These results suggest that early sustained may preserve limit deficits humoral immunity. circulating Tfh-like cells appears be independent treatment history ongoing warrants further investigation.
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Alberto Cagigi, Stefano Rinaldi, Veronica Santilli, Nadia Mora, Emma Concetta Manno, Nicola Cotugno, Paola Zangari, Angela Aquilani, Isabella Guzzo, Luca Dello Strologo, Paolo Rossi, Paolo Palma, Premature ageing of the immune system relates to increased anti-lymphocyte antibodies (ALA) after an immunization in HIV-1-infected and kidney-transplanted patients Clinical and Experimental Immunology. ,vol. 174, pp. 274- 280 ,(2013) , 10.1111/CEI.12173
A Bamford, A Turkova, H Lyall, C Foster, N Klein, D Bastiaans, D Burger, S Bernardi, K Butler, E Chiappini, P Clayden, M Della Negra, V Giacomet, C Giaquinto, D Gibb, L Galli, M Hainaut, M Koros, L Marques, E Nastouli, T Niehues, A Noguera-Julian, P Rojo, C Rudin, HJ Scherpbier, G Tudor-Williams, SB Welch, , Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV‐1 infection 2015: optimizing health in preparation for adult life Hiv Medicine. ,vol. 19, ,(2018) , 10.1111/HIV.12217
Isabelle Debock, Kathy Jaworski, Hanan Chadlaoui, Sandrine Delbauve, Nicolas Passon, Laure Twyffels, Oberdan Leo, Véronique Flamand, Neonatal Follicular Th Cell Responses Are Impaired and Modulated by IL-4 The Journal of Immunology. ,vol. 191, pp. 1231- 1239 ,(2013) , 10.4049/JIMMUNOL.1203288
Michela Locci, Colin Havenar-Daughton, Elise Landais, Jennifer Wu, Mark A Kroenke, Cecilia L Arlehamn, Laura F Su, Rafael Cubas, Mark M Davis, Alessandro Sette, Elias K Haddad, Pascal Poignard, Shane Crotty, None, Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses Immunity. ,vol. 39, pp. 758- 769 ,(2013) , 10.1016/J.IMMUNI.2013.08.031
Rafael A Cubas, Joseph C Mudd, Anne-Laure Savoye, Matthieu Perreau, Julien Van Grevenynghe, Talibah Metcalf, Elizabeth Connick, Amie Meditz, Gordon J Freeman, Guillermo Abesada-Terk Jr, Jeffrey M Jacobson, Ari D Brooks, Shane Crotty, Jacob D Estes, Giuseppe Pantaleo, Michael M Lederman, Elias K Haddad, None, Inadequate T follicular cell help impairs B cell immunity during HIV infection Nature Medicine. ,vol. 19, pp. 494- 499 ,(2013) , 10.1038/NM.3109
Kristin L. Boswell, Robert Paris, Eli Boritz, David Ambrozak, Takuya Yamamoto, Sam Darko, Kaska Wloka, Adam Wheatley, Sandeep Narpala, Adrian McDermott, Mario Roederer, Richard Haubrich, Mark Connors, Julie Ake, Daniel C. Douek, Jerome Kim, Constantinos Petrovas, Richard A. Koup, Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection PLoS Pathogens. ,vol. 10, pp. e1003853- ,(2014) , 10.1371/JOURNAL.PPAT.1003853
Yuhui Shi, Kazunaga Agematsu, Hans D Ochs, Kazuo Sugane, Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. Clinical Immunology. ,vol. 108, pp. 128- 137 ,(2003) , 10.1016/S1521-6616(03)00092-5
Susan Moir, Anthony S. Fauci, B cells in HIV infection and disease Nature Reviews Immunology. ,vol. 9, pp. 235- 245 ,(2009) , 10.1038/NRI2524
Alasdair Bamford, Peter Kelleher, Hermione Lyall, Mitch Haston, Marta Zancolli, David Goldblatt, Beate Kampmann, Serological response to 13-valent pneumococcal conjugate vaccine in children and adolescents with perinatally acquired HIV infection. AIDS. ,vol. 28, pp. 2033- 2043 ,(2014) , 10.1097/QAD.0000000000000385
Adriana Weinberg, Ruth Dickover, Paula Britto, Chengcheng Hu, Julie Patterson-Bartlett, Joyce Kraimer, Howard Gutzman, William T Shearer, Mobeen Rathore, Ross McKinney, Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy. AIDS. ,vol. 22, pp. 2267- 2277 ,(2008) , 10.1097/QAD.0B013E3283189BB3