Cortico-accumbens fiber stimulation does not induce dopamine release in the nucleus accumbens in vitro.

摘要: Interactions between dopamine (DA) and glutamate in the nucleus accumbens (NA) are important for a variety of cognitive limbic functions. Although, there is strong evidence that DA controls responses, converse (glutamate affecting release) controversial. To determine whether endogenous released from corticostriatal terminals can evoke release by local interactions NA, we measured with amperometry simultaneously whole cell recordings NA medium spiny neurons (MSNs) slice preparation preserving (but not bodies) cortico-accumbens fibers. MSNs responded to cortical stimulation postsynaptic potential was blocked AMPA antagonist CNQX, but no overflow detected carbon fiber electrode. This absence cannot be accounted deterioration this since evoked caudal same slices. The signal modulated as expected bath application transporter blocker. data show cortico-striatal activation does induce interactions, suggesting observations glutamate-evoked previously reported vivo may taking place via an extra-NA circuit.