Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth.

摘要: Recent work has demonstrated that enzymatic degradation of collagen fibers exhibits strain-dependent kinetics. Conceptualizing how the strain dependence affects remodeling collagenous tissues is vital to our understanding management in native and bioengineered tissues. As a first step towards this goal, current study puts forward multiscale model for networks two sample geometries we routinely use experiments as The model, driven by microstructural data from an decay experiment, includes exponential kinetic relation constant growth. For dogbone under uniaxial load, predicted distribution fiber diameters would spread over course because variation individual load. In cross-shaped sample, central region, which experiences smaller, more isotropic loads, showed less diameter compared arms. There was also slight shift average orientation different regions cruciform.