Multiscale mechanical simulations of cell compacted collagen gels.

摘要: Engineered tissues are commonly stretched or compressed (i.e., conditioned) during culture to stimulate extracellular matrix (ECM) production and improve the mechanical properties of growing construct. The relationships between stimulation ECM remodeling, however, complex, interdependent, dynamic. Thus, theoretical models required for understanding underlying phenomena so that conditioning process can be optimized produce functional engineered tissues. Here, we continue our development multiscale by simulating effect cell tractions on developing isometric tension redistributing forces in surrounding fibers a collagen gel embedded with explants. model predicted patterns fiber reorganization were similar those observed experimentally. Furthermore, inclusion compaction also changed distribution strains compared acellular case, particularly regions around cells where highest found.